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Human Tumor Necrosis Factor α (TNF α) Protein, Recombinant
ID P01T0007
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America americas@bluegene.cc
Asia & Australia asia@bluegene.cc
Europe & Africa europe-raina@bluegene.cc
Europe & Africa europe@bluegene.cc
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Other Names
DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F

Background
TNF-α (tumor necrosis factor) gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cx`ytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine.