Serine/Threonine kinases Proteins function

Serine/threonine protein kinase has a potential catalytic ability to transfer the γ-phosphate group in ATP to the specific amino acid residues of protein substrate to make protein phosphorylate. It mainly plays a regulatory role in DNA replication and mitosis, as well as in the process of transcription. For example, the process of nuclear translocation of transcription factors regulates the binding ability of transcription factors and DNA and regulates the activation activity of transcription factors. Moreover, phosphorylation is closely related to tumorigenesis, which can promote changes in gene expression and other cellular responses.

Serine/Threonine kinases Proteins examples

The holoenzyme, as a cAMP-dependent protein kinase existing in the cytoplasm, is called protein kinase A (PKA). It is activated by cAMP and can catalyze subunits to regulate metabolism, regulate ion channels, regulate other signal transduction pathway proteins, and enter the nucleus to regulate gene expression.

BlueGene Serine/Threonine kinases Proteins

Serine/Threonine kinases Proteins

Serine threonine protein kinase (STPK) is the most important class of protein kinases. And it has great significance as a drug for designing targets in many clinical fields except oncology.

For example, two subfamilies of STPK: protein kinase C (PKC) and cyclin-dependent kinase (CDK). They are often used as an anti-cancer drugs to design targets. STPK regulates various life activities of cells by catalyzing the phosphorylation of various functional proteins (such as enzymes, receptors, transport proteins, regulatory proteins, nuclear proteins, etc.). In addition, the study of STPK has important scientific significance for clarifying the molecular mechanism of salt tolerance.

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FAQs about Serine/Threonine kinases Proteins

Q
Serine/Threonine kinases Proteins function

Serine/threonine protein kinase has a potential catalytic ability to transfer the γ-phosphate group in ATP to the specific amino acid residues of protein substrate to make protein phosphorylate. It mainly plays a regulatory role in DNA replication and mitosis, as well as in the process of transcription. For example, the process of nuclear translocation of transcription factors regulates the binding ability of transcription factors and DNA and regulates the activation activity of transcription factors. Moreover, phosphorylation is closely related to tumorigenesis, which can promote changes in gene expression and other cellular responses.
Q
Serine/Threonine kinases Proteins examples

The holoenzyme, as a cAMP-dependent protein kinase existing in the cytoplasm, is called protein kinase A (PKA). It is activated by cAMP and can catalyze subunits to regulate metabolism, regulate ion channels, regulate other signal transduction pathway proteins, and enter the nucleus to regulate gene expression.