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BlueGene Biotech P01I0310 Human Interleukin 18 (IL-18) Protein, Recombinant

  • Immunology
  • Cardiovascular

Interleukin 18 (IL-18) can also be called IGIF; IL-18; IL-1g; IL1F4

Products

Specifications Of P01I0310 Human Interleukin 18 (IL-18) Protein, Recombinant

Product Information

catalog number

P01I0310

Package Size

10ug/50ug/500ug/1mg

Other Names

IGIF; IL-18; IL-1g; IL1F4

Protein & NCBI Number

Q14116, NM_001562

Host

E.coli

Express Region

Met1-Asp193

Protein Sequence

MGSSHMASMSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLME
AFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGGMAAEPVED
NCINFVAMKFIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQGNRPLFE
DMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPD
NIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIM
FTVQNEDKHHHHHH

Molecular Weight

The protein consists of 306 amino acids (including the fusion tag), with a
predicted molecular weight of 35.31kDa

Fusion Tag

SUMO(N-terminus), 6×His (C-terminus)

Purity

≥95% SDS-PAGE

Physical Property

Liquid

Components

0.01M PBS+20% glycerol, sterile solution

Storage & Stability

After aliquoting, the stability of the samples can be maintained for up to 6
months at -20°C to -80°C, avoiding repeated freeze-thaw cycles

Applications

Antibody preparation, immunoassay (ELISA, WB), subcellular localization
and interaction protein identification, etc

Lead Time

5 to 10 business days;

2 to 3 days for stock products


Background

Interleukin-18 belongs to the interleukin-1 family. Interleukin 18 (IL-18) is a potent pro-inflammatory cytokine that can induce the production of interferon-γ (IFN-γ) by Th1 cells, natural killer (NK) cells, and activated macrophages, particularly in the presence of IL-12. IL-18 also participates in regulating the development of T lymphocyte helper type I cells and Fas-mediated cytotoxicity. Inhibition of IL-18 activity is being investigated as a therapeutic approach for the treatment of chronic inflammatory diseases such as Crohn's disease and rheumatoid arthritis. It operates by inducing heterodimerization of its receptors, IL-18RAlpha and IL-18RBeta, which is structurally similar to IL-1.

The regulatory mechanism of Interleukin-18 is very complex, and its production is modulated by a variety of signaling pathways. Cytokines such as Tumor Necrosis Factor (TNF) and Interleukin (IL-1) can stimulate the production of interleukin-18. Additionally, the Toll-like receptor (TLR) signaling pathway and the NLRP3 Inflammasome are also involved in the regulation of Interleukin-18. Furthermore, certain transcription factors, such as NF-κB and AP-1, can directly or indirectly influence the production of interleukin-18.


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