Interleukin 4 (IL-4) can also be called BSF1; IL-4; BCGF1; BSF-1; BCGF-1
Specifications Of P01I0007 Human Interleukin 4 (IL-4) Protein, Recombinant
| Product Information | |
catalog number | P01I0007 |
Package Size | 10ug/50ug/500ug/1mg |
Other Names | BSF1; IL-4; BCGF1; BSF-1; BCGF-1 |
Protein & NCBI Number | P05112、NM_000589.4 |
Host | E.coli |
Express Region | Met1-Ser153 |
Protein Sequence | MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQ KTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQ LIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS |
Molecular Weight | The protein consists of 153 amino acids (including the fusion tag), with a predicted molecular weight of 31.8kDa, which matches the actual molecular weight. |
Fusion Tag | 6×His-SUMO (N-terminus) |
Purity | ≥90% SDS-PAGE |
Physical Property | Liquid |
Components | 0.01M PBS+20% glycerol, sterile solution |
Storage & Stability | After aliquoting, the stability of the samples can be maintained for up to 6 months |
Applications | Antibody preparation, immunoassay (ELISA, WB), subcellular localization and |
Lead Time | 5 to 10 business days; 2 to 3 days for stock products |
Background |
IL-4 is a pleiotropic cytokine produced by activated T cells. It undergoes N glycosylation sites and different degrees of glycosylation under different conditions. The precursor of IL-4 is 153 peptide, and the mature IL-4 is 129 peptide after removing the signal peptide.The biological effects of IL-4 are mediated by binding to the IL-4 receptor (IL-4R).The Interleukin 4 receptor also binds to IL13, which may result in many overlapping functions of this cytokine and IL-13.STAT6 is a signal transduction and transcriptional activator that has been shown to play a central role in mediating immunomodulatory signaling of this cytokine. IL-4 is considered to be an important cytokine for tissue repair, counteracting the effects of type 1 proinflammatory cytokines; however, it also promotes allergic airway inflammation.In addition, IL-4, as a characteristic cytokine of Th2 cells, plays a role in promoting the occurrence and development of inflammatory responses characterized by Th2, mediating and regulating a variety of human host responses, such as allergy, anti-parasite, wound healing, and acute inflammation.Il-4 significantly upregates THE CXC chemokine receptor on THE surface of CD4+T cells to mediate the inflammatory response, which may be mediated by cAMP or cGMP signal transduction pathways. IL-4 has been reported to promote the regression of neutrophil-mediated acute lung injury.In allergic reactions, IL-4 plays an important role in the production of allergen-specific immunoglobulin IgE. An increase in this pro-inflammatory cytokine has been observed in PATIENTS with COVID-19, but is not necessarily associated with severe COVID-19 pathology.Two variable-splice transcripts of this gene encoding different isoforms have been reported. |
BlueGene Biotech Product Show
Related Products Of Human Interleukin 4 (IL-4) Protein, Recombinant
P01I0010 Human Interleukin 1β (IL-1β) Protein, Recombinant
P01I0023 Human Interleukin 10 (IL-10) Protein, Recombinant
P01I0056 Human Interleukin 8 (IL-8) Protein, Recombinant
P01I0308 Human Interleukin 2 (IL 2) Protein, Recombinant
P01I0006 Human Interleukin-6 (IL-6) Protein, Recombinant
